Nature-Skin-Derived Multi-Responsive E-Skin as On-Demand Drug-Delivery System Facilitated Melanoma Postoperative Therapy
Published in Journal of Materials Science \& Technology, 2024
Abstract: Electronic skins (e-skins) have the potential to turn into breakthroughs in biomedical applications. Herein, a novel acellular dermal matrix (ADM)-based bioelectronic skin (e-ADM) is used to fabricate versatile “wound therapy-health monitoring” tissue-nanoengineered skin scaffolds via a facile “one-pot” bio-compositing strategy to incorporate the conductive carbon nanotubes and self-assembled micro-copper oxide microspheres with a cicada-wing-like rough surface and nanocone microstructure. The e-ADM exhibits robust tensile strength (22 MPa), flexibility, biodegradability, electroactivity, and antibacterial properties. Interestingly, e-ADM exhibits the pH-responsive ability for intelligent command between sterilization and wound repair . Additionally, e-ADM enables accurate real-time monitoring of human activities, providing a novel flexible e-skin sensor to record injury and motions. In vitro and in vivo experiments show that with electrical stimulation, e-ADM could prominently facilitate cell growth and proliferation and further promote full-thickness skin wound healing, providing a comprehensive therapeutic strategy for smart sensing and tissue repair, guiding the development of high-performance “wound therapy-health monitoring” bioelectronic skin-scaffolds.
Recommended citation: M Zheng, X Wang, J Zhang, O Yue, J Zhang, Z Bai, H Jiang, J Wu, L Wen, ... (2024). "Nature-Skin-Derived Multi-Responsive E-Skin as On-Demand Drug-Delivery System Facilitated Melanoma Postoperative Therapy." Journal of Materials Science & Technology, 188, 155-168.
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